Code Critters: A Block-Based Testing Game

Learning to program has become common in schools, higher education and individual learning. Although testing is an important aspect of programming, it is often neglected in education due to a perceived lack of time and knowledge, or simply because testing is considered less important or fun. To make testing more engaging, we therefore introduce Code Critters, a Tower Defense game based on testing concepts: The aim of the game is to place magic mines along the route taken by small "critters" from their home to a tower, such that the mines distinguish between critters executing correct code from those executing buggy code. Code is shown and edited using a block-based language to make the game accessible for younger learners. The mines encode test inputs as well as test oracles, thus making testing an integral and fun component of the game

genus & generatio. Rollenerwartungen und Rollenerfüllungen im Spannungsfeld der Geschlechter und Generationen in Antike und Mittelalter

Die Beiträge in diesem Band gehen zurück auf die dritte Nachwuchstagung des Bamberger DFG-Graduiertenkollegs „Generationenbewusstsein und Generationenkonflikte in Antike und Mittelalter“. Neben Aspekten der Generationenthematik stehen dabei vor allem Überlegungen zu den genderstudies und die Frage nach den Valenzen des Rollenbegriffs im Vordergrund, wodurch sich vielfältige interdisziplinäre Berührungs- und Schnittpunkte ergeben. Der Band umfasst Beiträge der Fächer Klassische Philologie, Geschichtswissenschaft, Romanistik und Germanistik in einem Untersuchungszeitraum von der Antike bis ins ausgehende Mittelalter

Dataset to "Identifiability Analysis and Parameter Estimation of Microgel Synthesis: A Set-Membership Approach"

Functional microgels with tailored structure and specific properties are required for medical and technical applications, thus motivating model-based optimization of their fabrication processes. An important step in the creation of accurate models is parameter estimation. We present a methodology for a parameter identifiability analysis, which approximates the feasible parameter set as a box by solving a series of constrained dynamic optimization problems. The method is applied to the synthesis of microgels based on two monomers, N-vinylcaprolactam and N-isopropylacrylamide, and the cross-linker N,N-methylenebis(acrylamide). The results show that kinetic parameters corresponding to the reaction of the monomers are identifiable as are a subset of the kinetic parameters involving the cross-linker. The reaction kinetics of the cross-linking are faster in comparison to the main polymerization reaction for N-vinylcaprolactam; this allows for an improved understanding of the occurring reaction phenomena. The reaction kinetics of the cross-linking are not identifiable for N-isopropylacrylamide for the given experimental setup; model-based experimental design for parameter precision might enable their identification. The results also indicate potential for model simplification and allow us to make suggestions toward the enhancement of Raman spectroscopy measurements

RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5

The molecular target(s) cooperating with proteasome inhibition in multiple myeloma (MM) remain unknown. We therefore measured proliferation in MM cells transfected with 13 984 small interfering RNAs in the absence or presence of increasing concentrations of bortezomib. We identified 37 genes, which when silenced, are not directly cytotoxic but do synergistically potentiate the growth inhibitory effects of bortezomib. To focus on bortezomib sensitizers, genes that also sensitized MM to melphalan were excluded. When suppressed, the strongest bortezomib sensitizers were the proteasome subunits PSMA5, PSMB2, PSMB3, and PSMB7 providing internal validation, but others included BAZ1B, CDK5, CDC42SE2, MDM4, NME7, RAB8B, TFE3, TNFAIP3, TNK1, TOP1, VAMP2, and YY1. The strongest hit CDK5 also featured prominently in pathway analysis of primary screen data. Cyclin-dependent kinase 5 (CDK5) is expressed at high levels in MM and neural tissues with relatively low expression in other organs. Viral shRNA knockdown of CDK5 consistently sensitized 5 genetically variable MM cell lines to proteasome inhibitors (bortezomib and carfilzomib). Small-molecule CDK5 inhibitors were demonstrated to synergize with bortezomib to induce cytotoxicity of primary myeloma cells and myeloma cell lines. CDK5 regulation of proteasome subunit PSMB5 was identified as a probable route to sensitization